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aginglab

๊ด€๋ฆฌ์ž
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20๋ฌธ์„œ
2026๋…„ 07์›” 01์ผ ๊ฐ€์ž…
์ž‘์„ฑ ๋ฌธ์„œ
์—‘์†Œ๋‰ดํด๋ ˆ์•„์ œ 9์‹œ๊ฐ„ ์ „
mRNA ์•ˆ์ •์„ฑ 9์‹œ๊ฐ„ ์ „
mRNA ์บก ๊ตฌ์กฐ์˜ 5' ๋ง๋‹จ ๋ณดํ˜ธ ๋ฉ”์ปค๋‹ˆ์ฆ˜๊ณผ ์—‘์†Œ๋‰ดํด๋ ˆ์•„์ œ ์ €ํ•ญ์„ฑ 9์‹œ๊ฐ„ ์ „
๊ตฌ์กฐ ๋‹จ๋ฐฑ์งˆ 9์‹œ๊ฐ„ ์ „
๋‰ดํด๋ ˆ์˜ค์†œ ์ฃผ๋ณ€ ๋น„์ ์œ  ์˜์—ญ(NFR)์˜ ๊ตฌ์กฐ์  ์•ต์ปค๋ง๊ณผ ์œ ์ „์ž ๋ฐœํ˜„ ์กฐ์ ˆ 9์‹œ๊ฐ„ ์ „
Mitophagy 9์‹œ๊ฐ„ ์ „
NAD+/NADH ๋น„์œจ ๋ณ€ํ™”๋ฅผ ์ด์šฉํ•œ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ํ’ˆ์งˆ ๊ด€๋ฆฌ(Mitophagy) ์กฐ์ ˆ ํ•ฉ์„ฑ ์œ ์ „์ž ํšŒ๋กœ ์„ค๊ณ„ 9์‹œ๊ฐ„ ์ „
๋Œ€์‚ฌ์ฒด ์‹ ํ˜ธ ๊ธฐ๋ฐ˜์˜ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๊ธฐ๋Šฅ ์žฅ์•  ๊ฐ์ง€ ๋ฐ ์„ธํฌ ์šด๋ช… ์ „ํ™˜ ์‹œ์Šคํ…œ ๋ชจ๋ธ๋ง 9์‹œ๊ฐ„ ์ „
PCA (Principal Component Analysis) 9์‹œ๊ฐ„ ์ „
Harmony 9์‹œ๊ฐ„ ์ „
CCA (Canonical Correlation Analysis) 9์‹œ๊ฐ„ ์ „
๋‹จ์ผ์„ธํฌ ๊ณต๊ฐ„ ์ „์‚ฌ์ฒดํ•™ ๋ฐ์ดํ„ฐ์…‹์˜ ๋ฐฐ์น˜ ํšจ๊ณผ ์ œ๊ฑฐ๋ฅผ ์œ„ํ•œ ํ†ต๊ณ„์  ์ •๊ทœํ™” ๋ฐฉ๋ฒ•๋ก  9์‹œ๊ฐ„ ์ „
์„ธํฌ์šด๋ช…๊ฒฐ์ • 9์‹œ๊ฐ„ ์ „
๊ณต๊ฐ„ ์ „์‚ฌ์ฒดํ•™ ๊ธฐ๋ฐ˜ ๋ฆฌ๋ณดํ•ต๋‹จ๋ฐฑ์งˆ(RNP) ๋ณตํ•ฉ์ฒด์˜ ์„ธํฌ ์†Œ๊ธฐ๊ด€๋ณ„ ๋ถ„ํฌ ๋ถ„์„ 9์‹œ๊ฐ„ ์ „
๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๋‚ด \ฮฒ-์‚ฐํ™” ์‚ฐ๋ฌผ์— ์˜ํ•œ ์„ธํฌ์งˆ ์•„์„ธํ‹ธ-CoA ํ’€ ์กฐ์ ˆ ๋ฉ”์ปค๋‹ˆ์ฆ˜ 9์‹œ๊ฐ„ ์ „
ํŠน์ • ์กฐ๊ฑด ํ•˜์—์„œ์˜ ๋‹จ๋ฐฑ์งˆ-ํ•ต์‚ฐ ์ƒํ˜ธ์ž‘์šฉ ์ธํ„ฐํŽ˜์ด์Šค์˜ ๊ตฌ์กฐ์  ์•ˆ์ •์„ฑ ๋ถ„์„ 9์‹œ๊ฐ„ ์ „
CpG ์•„์ผ๋žœ๋“œ ์ฃผ๋ณ€ Histone Acetyltransferase(HAT)์˜ ์„ ํƒ์  ํ™œ์„ฑ ์กฐ์ ˆ ๋ฉ”์ปค๋‹ˆ์ฆ˜ 9์‹œ๊ฐ„ ์ „
CpG ์•„์ผ๋žœ๋“œ ์ฃผ๋ณ€ HDAC์˜ ์„ ํƒ์  ํ™œ์„ฑ ์กฐ์ ˆ ๋ฉ”์ปค๋‹ˆ์ฆ˜ 9์‹œ๊ฐ„ ์ „
Post-transcriptional Regulation 1์ผ ์ „
Translational Regulation 1์ผ ์ „